4:05 p.m. ET | CBS
Matchup rating: 36 | Spread: IND -10.5 (44)
What to watch for: What will the Colts' defense do against a banged-up Jets offense? The Colts are coming off a game with three sacks against the Vikings, and the Jets will likely be without their starting running back, center, right tackle and top three receivers. Indianapolis should be able to keep its status as the NFL's best defense by the end of Sunday. -- Mike Wells
Bold prediction: Colts defensive end Justin Houston and defensive tackle DeForest Buckner will combine for at least three sacks against the Jets' banged-up offensive line, which likely will be without center Connor McGovern and right tackle George Fant. Houston usually lines up over the left tackle, but he could flip sides. Rookie left tackle Mekhi Becton is the Jets' best lineman at the moment. -- Rich Cimini
Stat to know: Indianapolis receiver T.Y. Hilton now has 13 consecutive games with fewer than 100 receiving yards, dating back to 2018 -- the longest streak of his career. And he has seven consecutive games without a receiving TD, tied for the second-longest such streak of his career and his longest since 2015-16 (also seven straight).
What to know for fantasy: In his first career start, Jonathan Taylor was one of two backs to carry the ball 20 times and rack up over 100 rushing yards in Week 2. Since 2015, teams playing with a lead run the ball 46.6% of the time (30.9% when trailing), and the Colts are the biggest favorite of Week 3. See Week 3 rankings.
Betting nugget: The Jets are one of three teams to lose both games by double digits this season. Read more.
Cimini's pick: Colts 27, Jets 13
Wells' pick: Colts 31, Jets 13
FPI prediction: IND, 65.8% (by an average of 5.7 points)
Matchup must-reads: Darnold isn't a bust, but Colts-Jets 2018 trade now feels one-sided ... Bad handoff: Colts' Leonard gives fan his gloves with wedding ring inside ... Jets safety McDougald, LB Williamson question 'slow' practices amid 0-2 start ... Colts put Campbell, Hooker on injured reserve ... Jets need fresh legs on offense; it's time for rookie Perine ... Colts laid out blueprint for success with game plan vs. Vikings