1 p.m. ET | Fox
Matchup rating: 14.8 | Spread: DET -3 (55)
What to watch for: Look for Jaguars running back James Robinson to carry the ball more than 20 times. Jacksonville offensive coordinator Jay Gruden admitted he has abandoned the run way too soon in each of the Jaguars' past two games, so expect him to commit to Robinson pretty heavily against the Lions. And it makes sense because the Lions are giving up an NFL-worst 170.3 yards per game rushing. -- Mike DiRocco
Bold prediction: Lions quarterback Matthew Stafford will look like the quarterback he was last season, throwing for 330 yards and three touchdowns, in a game that will still come down to the final possession due to Detroit's poor defense against Gardner Minshew -- who will also throw for 300 yards and two scores. -- Michael Rothstein
Stat to know: Minshew needs 235 passing yards to have the most ever by a Jaguars QB through six games. He can also join Mark Brunell (1999) as the only players in Jaguars history with three straight 300-yard passing games.
What to know for fantasy: Robinson has at least 17 touches in every game this season, totaling at least 90 yards in four of those five games. See Week 6 rankings.
Betting nugget: Detroit is 7-1 ATS coming off a bye since the start of the 2012 season. Read more.
Rothstein's pick: Lions 27, Jaguars 24
DiRocco's pick: Lions 28, Jaguars 20
FPI prediction: DET, 60.2% (by an average of 3.6 points)
Matchup must-reads: What's wrong with Stafford's feet? ... Titans deal unhappy LB Correa to Jaguars ... Jaguars to use fifth kicker of season in Brown ... Jaguars among NFL teams using silver to fight COVID-19