1 p.m. ET | CBS
Matchup rating: 13.0 | Spread: CLE -6.5 (49)
What to watch for: The Jaguars' best chance for success is to get running back James Robinson going. He is on pace to break Dominic Rhodes' record for most yards from scrimmage by an undrafted rookie and has been the Jaguars' lone bright spot on offense. If the Browns, who rank eighth in run defense, can limit Robinson, they should be able to tee off on Mike Glennon -- who gets the start at quarterback for Jacksonville this week -- even though they won't have edge rusher Myles Garrett. It could be another long day for the Jaguars' QBs. -- Mike DiRocco
Bold prediction: After failing to throw a TD pass over three games for the first time in his career, in large part due to inclement weather, Browns quarterback Baker Mayfield will bounce back with three touchdown throws in Jacksonville. -- Jake Trotter
Stat to know: The Jaguars are the only team in danger of being eliminated from playoff contention in Week 12 (the Jets are already eliminated), which can happen with a loss. A 10th straight loss would mark the longest losing streak within a single season in franchise history. The Browns, meanwhile, are seeking to match their best 11-game start to a season in the past 30 seasons (8-3 in 1994).
What to know for fantasy: Robinson leads the league in carry share this season and is coming off his first game with both a 15-plus-yard rush and a 15-plus-yard catch. See Week 12 rankings.
Betting nugget: Mayfield is 1-5 ATS in his career as a road favorite (2-4 straight up). Read more.
Trotter's pick: Browns 28, Jaguars 14
DiRocco's pick: Browns 27, Jaguars 21
FPI prediction: CLE, 65.7% (by an average of 5.4 points)
Matchup must-reads: Winning ugly? Who cares? All that matters is Browns are winning ... Who is Jaguars' starting QB? ... Minus Garrett, Browns' defense delivers win over Eagles ... Jaguars defensive coaches working remotely amid COVID-19 protocols