What it means: As opposed to last week's loss to Tennessee, the Chiefs have no reason to be disheartened by this defeat. The Chiefs lost three starters for the season last week because of injuries and played most of this one without running Jamaal Charles and safety Eric Berry. Each left the game in the first half with an ankle injury and didn't return. The Chiefs still showed signs of life that were well-hidden last week, particularly on offense. At 0-2, the Chiefs have to find a way to regroup in time for next week's game at Miami.
Stock watch: Rookie kicker Cairo Santos had his second straight shaky game. He missed a 37-yard field goal in the third quarter that would have pulled the Chiefs to within a touchdown. Cornerback Marcus Cooper, a frequent victim of Denver quarterback Peyton Manning last season, was burned on a 48-yard pass to Emmanuel Sanders on the game's first play from scrimmage to set up the Broncos' first touchdown. Knile Davis did a nice job of filling in for Charles in the running game but he's still a liability when he's in the game on passing plays.
More injuries: The Chiefs' lineup was patched together at many spots. Berry was replaced by Ron Parker, who spent most of training camp as a cornerback. Davis is far from the versatile back the Chiefs need in their offensive system. They already had to dig deep to fill their lineup on the offensive line and at inside linebacker. Depth was a concern heading into training camp and it's evident those worries were valid.
Game ball: Quarterback Alex Smith was under heavy pressure all day but played well enough to keep the Chiefs alive. His running ability was also a key in the first half when he had some runs that kept drives alive.
What's next: The Chiefs head to Miami for a game against the 1-1 Dolphins at 4:25 p.m. ET next week.