4:05 p.m. ET | Fox
Matchup rating: 79.1 | Spread: TB -4 (51.5)
What to watch for: Who, exactly, will be playing offensive line for the Raiders, whose entire starting O-line is on the COVID-19 list after right tackle Trent Brown tested positive this week? If it's a bunch of backups, pity Raiders quarterback Derek Carr against Tampa Bay, which has the second-most sacks in the NFL with 22. Yeah, this has the makings of a familiar disaster for the Raiders -- think Super Bowl XXXVII. -- Paul Gutierrez
Bold prediction: Tampa Bay running back Ronald Jones will have 100 yards rushing, and the offense as a whole will score four times. The Bucs have scored the second-most points in the NFL this season and face a Raiders defense that has given up 30 or more points in four of five games. With almost all of Tom Brady's receiving weapons returning to health -- most notably Chris Godwin -- these numbers aren't too much to ask from this group, although the Tampa Bay defense, like last weekend, will likely be the real difference-maker. -- Jenna Laine
Stat to know: The Buccaneers allow a league-low 282.0 yards per game, have the best pass-rush win rate (55%) in the NFL, blitz at the second-highest rate (41%) and give up the fewest rush yards per game (64.3).
Betting nugget: The over is 5-0 in Las Vegas games this season. Read more.
Laine's pick: Buccaneers 38, Raiders 28
Gutierrez's pick: Buccaneers 48, Raiders 21
FPI prediction: TB, 56.2% (by an average of 2.2 points)
Matchup must-reads: What Brady's jerseys have meant to him and lessons he's learned along the way ... Raiders' Jacobs becoming better all-around back under Allen's tutelage ... Carr, MVP candidate? A Raiders bye-week progress report