1. According to the Elias Sports Bureau, the Patriots will be the eighth team all-time to play on Monday Night Football with a record of 9-0-0 or better, and the first since the 2009 Saints were 10-0 and defeated the Patriots, 38-17. A win will secure the Patriots’ 13th straight 10-win season, with only the 49ers’ streak of 16 straight between 1983-98 being longer.
2. Patriots quarterback Tom Brady is 24-3 in his career against the Bills. According to Elias Sports Bureau, Brady’s 24 wins are his most against any team and the second most by a starting quarterback against a single team since the 1970 merger.
3. The Bills rank sixth in the NFL, averaging 25.7 points per game. That’s on pace to be their highest season total since 1991 (28.6 points per game). This is their first Monday Night Football game since visiting the Patriots in the 2009 season-opener.
4. The Bills average 3.1 yards before contact per rush this season, which is second in the NFL behind the Steelers (3.2). They have five rushing touchdowns of at least 20 yards, which is two more than any other team.
5. Rookie Bills running back Karlos Williams has joined Robert Edwards (1998 Patriots) as the only players in NFL history to score a TD in their first six career games. Williams is a fifth-round draft choice out of Florida State.
6. The Patriots have won an NFL-record 79 straight home games when leading at halftime. The last time they lost at home after leading at the half was Dec. 24, 2000 vs. Miami. The Patriots have never lost a game at Gillette Stadium (opened in 2002) when leading at halftime (73-0 since 2002).
7. When the Patriots defeated the Bills, 40-32, in Week 2, running back Dion Lewis (138) and receiver Julian Edelman (109) accounted for 247 of New England's 507 total yards (48.7 percent) and scored three touchdowns. Lewis is now on IR with a torn ACL, while Edelman broke his foot last week.
8. The Patriots have scored points in 35 straight quarters, which breaks the NFL record previously shared by the 1999-2000 Rams and 2005 Colts at 31. The only quarter in which the Patriots haven't scored points this season was the first quarter of the season opener against the Steelers.
9. Brady enters the game with 416 regular-season touchdown passes, which puts him within striking distance of No. 3 on the all-time list (Dan Marino, 420). Peyton Manning (539) and Brett Favre (508) are No. 1 and 2. Brady is 13-6 on Monday Night Football, having lost two straight. His 43 passing touchdowns on Monday Night Football trail only Marino (74) and Favre (69).
10. Partly because of an early-season rotation, and more recently because of injuries, the Patriots have utilized a league-high 20 different offensive line combinations this year. The Panthers (17), Titans (16) and Texans (16) are next in line in terms of most o-line combinations.