1 p.m. ET | CBS
Matchup rating: 63 | Spread: NE -6 (48)
What to watch for: How the Patriots plan to cover Raiders tight end Darren Waller (18 receptions) is the game within the game. In Week 1, second-year defensive back Joejuan Williams was primarily assigned to cover Dolphins tight end Mike Gesicki, but that's because the Patriots viewed Gesicki as more of a wide receiver. Waller has a more complete skill set that makes him a true tight end, and the Raiders move him around a lot, even putting him in the backfield at times. So finding and locating Waller is the first challenge. -- Mike Reiss
Bold prediction: Patriots quarterback Cam Newton will rush for at least two touchdowns. At 6-foot-5, 245 pounds, he is bigger than any linebacker or defensive back the Raiders have on their active roster. So you know Newton, called a "power forward" by Raiders coach Jon Gruden, is champing at the bit to run the read-option. -- Paul Gutierrez
Stat to know: The Raiders have the second-highest offensive efficiency rating (90.6) in the NFL through Week 2 (Packers, 94.0). They have scored 30-plus points in their first two games but have not done so in three straight games since 2016 (Weeks 7-9), the last season they made the playoffs.
What to know for fantasy: Waller saw a career-high 16 targets in Week 2, and his 24 targets through two weeks are the third-most in the NFL. See Week 3 rankings.
Betting nugget: New England is 51-26 ATS after a loss in the coach Bill Belichick era, including 40-15 ATS since 2003. Read more.
Gutierrez's pick: Patriots 35, Raiders 34
Reiss' pick: Patriots 31, Raiders 17
FPI prediction: NE, 63.4% (by an average of 4.8 points)
Matchup must-reads: Bill Belichick: Raiders' Waller going to be 'big challenge' for Patriots ... Raiders coach Jon Gruden calls Patriots' Cam 'Slam' Newton a power forward playing quarterback ... Runnin' Rebels, bitten ears and 'Fan Man': Top 10 moments in Las Vegas sports history ... Randall Cunningham proudly watches Patriots' Newton tie rushing mark ... Patriots' Cam Newton: Money, potential extension with Patriots not priorities