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Can Saints QB Drew Brees shake off the rust vs. Vikings?

Vikings (6-8) at Saints (10-4)

Friday, 4:30 p.m. ET | Fox/NFL Network

Matchup rating: 69.7 | Spread: NO -6.5 (51)

What to watch for: An intriguing matchup between New Orleans' top-three defense and Minnesota's top-five offense. The Saints and quarterback Drew Brees are hoping to shake off some rust after a two-game losing streak -- and clinch their fourth straight NFC South title in the process. They still have an outside shot at the NFC's No. 1 seed too. But to accomplish all that, they'll have to beat their nemesis. The Vikings have knocked them out of the playoffs twice in the past three years. -- Mike Triplett

Bold prediction: The Vikings' playoff hopes have been dashed, but that doesn't mean there's nothing left for this team to play for. With another eight-catch day, Justin Jefferson will accumulate the 132 yards to surpass Randy Moss as the NFL's leader in receiving yards by a rookie. He'll also score two touchdowns in his Louisiana homecoming. -- Courtney Cronin

Stat to know: Since Week 5, the Saints have pressured opposing quarterbacks on a league-high 39% of dropbacks. Kirk Cousins has been pressured on at least 40% of dropbacks in two straight weeks (both losses) and is 1-7 this season when taking pressure at least 30% of the time.

Playoff/draft picture: The Saints can clinch the NFC South with a win or a Buccaneers loss. The Vikings will be eliminated from the playoffs with a loss or a Cardinals win. FPI gives the Vikings a 6.4% chance to have a top-10 pick in next year's draft.

Injuries: Vikings | Saints

What to know for fantasy: Emmanuel Sanders has been targeted on 23.8% of his routes when Michael Thomas is not on the field this season (up from 17.7% with Thomas on the field). See Week 16 rankings.

Betting nugget: New Orleans is 4-1 ATS against teams with losing records this season. Read more.

Cronin's pick: Saints 27, Vikings 20

Triplett's pick: Saints 26, Vikings 22

FPI prediction: NO, 72.5% (by an average of 8.0 points)

Matchup must-reads: Vikings' lessons from a lost season: Don't waste young stars, lines need help and more ... Can 'Super Bowl or bust' Saints finally peak at the right time? ... Vikings' Justin Jefferson closes in on rookie receiving records ... Saints defense's plight: Short week after team-record 92 snaps vs. Patrick Mahomes