With about 2:23 left to play on Friday and the Knicks down 12, the chant started raining down.
Calls of "Fire D'Antoni!" mixed in with loud boos for New York, which was well on its way to a fifth straight loss.
Mike D'Antoni heard the crowd's reaction.
"I don't blame them," D'Antoni said. "Half my family is probably doing that. It goes with the territory. We're not playing well."
The Knicks are 6-9 and have struggled mightily on the offensive end. That continued on Friday.
They shot 37 percent against Milwaukee and were outscored 50-28 in the paint, missing several shots from in close.
"It's not a beautiful feeling right now with us losing five straight," Amare Stoudemire said. "We're not taking care of home court."
D'Antoni, who is in the final year of his contract, said there were no 'magic words he or anyone else could offer to get the Knicks out of their slump.
"They know where they are, they know the situation they're in. They've gotta dig deep, that inner strength to get through this," he said.