1 p.m. ET | FOX
Matchup rating: 56.9 | Spread: LAR -1 (46)
What to watch for: Rams defensive tackle Aaron Donald has zero sacks and just one tackle for loss in three career games against Philadelphia. He has a favorable matchup in this one, however, with inexperienced second-year player Nate Herbig projected to start at right guard. Center Jason Kelce will need to chip in on double-teams to prevent Carson Wentz, who was sacked a league-high eight times in Week 1, from having another rough day. -- Tim McManus
Bold prediction: Donald will have a monster, multisack game to that end. In a season-opening win over Dallas, Donald knocked down Cowboys linemen like they were bowling pins and recorded his first sack of the season. Now watch for the two-time NFL Defensive Player of the Year to take advantage of an inexperienced Eagles guard and make it another long day for Wentz. -- Lindsey Thiry
Stat to know: This marks the second career meeting between the top two picks of the 2016 NFL draft, Wentz and Jared Goff. Wentz won the first back in 2017 with four passing touchdowns. But both enter off underwhelming Week 1 performances. Goff threw zero touchdowns for the fourth time in his past nine games, while Wentz took eight sacks.
Betting nugget: Philadelphia is 5-0-1 against the spread (ATS) against the Rams since 2006. Read more.
Thiry's pick: Rams 24, Eagles 21
McManus' pick: Eagles 27, Rams 24
FPI prediction: PHI, 53.8% (by an average of 1.4 points)
Matchup must-reads: SoFi Stadium videoboard: 'Eighth wonder of the world' targets GenZ ... Time is now for the Eagles' Wentz to turn the corner ... McVay's Rams 'ecosystem' a challenging standard -- even for its creator ... Eagles' Curry, James have 'significant injuries'