With Cowboys' defense ailing, expect Seahawks' Russell Wilson to air it out

Cowboys (1-1) at Seahawks (2-0)

4:25 p.m. ET | FOX

Matchup rating: 74.7 | Spread: SEA -5 (56)

What to watch for: Russell Wilson and the Seahawks' passing game has a favorable matchup against Dallas' banged-up defense. The Seahawks have leaned more on Wilson over the first two games, and he has delivered, including a five-touchdown performance last week against New England's strong secondary. Now he faces a Cowboys defense that won't have cornerback Chidobe Awuzie or linebacker Leighton Vander Esch. With Seattle dealing with defensive issues of it own, this game has shootout potential. -- Brady Henderson

Bold prediction: Wilson will throw for more than 300 yards. Yes, he has thrown for 610 yards with nine touchdowns and 11 incompletions in the first two games, but before you question my boldness, consider this: In five games against the Cowboys for his career, Wilson is averaging just 154.4 yards through the air. He has completed 78 of 125 passes for 772 yards in five games. -- Todd Archer

Stat to know: Wilson has completed 52 of 63 passes this season (82.5%) for the highest completion percentage in NFL history by a QB with at least 50 pass attempts through two games. And now he is looking to become the fifth player ever to throw four pass touchdowns in three consecutive games (Peyton Manning, Dan Marino, Patrick Mahomes and Drew Brees).

Injuries: Cowboys | Seahawks

What to know for fantasy: Both Wilson and Dak Prescott are top-five QBs through two weeks, but Seattle has a pair of top-15 wide receivers, while the Cowboys don't have even one. See Week 3 rankings.

Betting nugget: Dallas has covered eight of its last 10 as an underdog. Read more.

Archer's pick: Seahawks 35, Cowboys 31

Henderson's pick: Seahawks 34, Cowboys 28

FPI prediction: SEA, 60.6% (by an average of 3.8 points)

Matchup must-reads: With Seahawks up next, Cowboys need to find winning ways on the road ... Seahawks' Metcalf projects greatness with performance vs. Gilmore ... How come-from-behind wins have altered Cowboys' past seasons ... Seahawks' defense comes up big late against Patriots, but questions remain ... Why did the Cowboys go for 2 down 9 points? It's all about knowing the future