Saturday, 4:40 p.m. ET | Fox
Matchup rating: 79.7 | Spread: SEA -3.5 (42.5)
What to watch for: Injuries could play a big role in this one. Rams coach Sean McVay has been tight-lipped about whether quarterback Jared Goff and his surgically repaired thumb will start Saturday. Seahawks safety Jamal Adams, meanwhile, said unequivocally that he'll be on the field for his first career playoff game. Adams' status had been in question because of a shoulder injury. Will either or both of them suit up, and how will their injuries play a part? -- Brady Henderson
Bold prediction: Rams No. 2 quarterback John Wolford will break the Rams' two-game streak without an offensive touchdown. Yes, Wolford. McVay won't declare a starter before kickoff, but expect Goff to give it a try. But with Goff less than two weeks removed from thumb surgery, Wolford could very well need to step in at some point. -- Lindsey Thiry
Stat to know: Seahawks quarterback Russell Wilson had six passing touchdowns of 30-plus air yards this season, tied with Patrick Mahomes for the most in the NFL. However, he went 2-of-16 (13%) with zero TDs and an interception on those throws over the last eight games of the season. And he went 1-of-6 on those throws against the Rams, who allowed an NFL-low completion percentage on deep balls this season (14.8%).
Matt Bowen's game key: The Seahawks have transitioned back to their old-school offensive identity over the second half of the season with a more run-heavy approach and play-action throws for Wilson. Why? This passing game looks disjointed, and Seattle has to get back to more rhythm concepts that allow him to get the ball out with speed. Read more.
Betting nugget: The Seahawks were 4-6 ATS this season when favored by more than a field goal, and the Rams are 3-1 ATS when getting at least 3.5 points during the McVay era. Read more.
Thiry's pick: Seahawks 20, Rams 17
Henderson's pick: Seahawks 21, Rams 18
FPI prediction: SEA, 59.1% (by an average of 3.0 points)
Matchup must-reads: "The McVay of defense": Former Division III coordinator Staley latest Rams coaching wunderkind ... Diving in: Swimming among ways Seahawks' Metcalf, Wilson have bonded ... Rams coach McVay "not gonna make an announcement" on starting QB ... Adams' availability a key to Seahawks avoiding another early exit