Sando's best guesses: Week 6 predictions

We've discussed the 10-0 home record NFC West teams have posted to this point in the season. I'm staying with the theme for Week 6:

  • St. Louis Rams at Miami Dolphins, 1 p.m. ET: The Rams' running stats improved against Arizona, but the Dolphins have been extremely stout against the run. They're allowing a league-low 2.7 yards per rush with only 11 rushing first downs, five fewer than any other team has allowed. They're a threat to make the Rams one-dimensional, a problem for St. Louis (0-3 on the road) without Danny Amendola. The Rams' best shot is for their outstanding corners to force Dolphins rookie Ryan Tannehill into turnovers. Don't forget about Legatron, either. Greg Zuerlein should scare the Dolphins, who have lost twice on overtime field goals. Sando's best guess: Dolphins 20, Rams 16

  • New England Patriots at Seattle Seahawks, 4:05 p.m. ET: The Seahawks are the team New England plays in between facing Peyton Manning's Denver Broncos and the AFC East-rival New York Jets. The Patriots are a team Seattle can measure itself against. The big question is whether the Seahawks can score enough points. How many is enough? Seattle has allowed 19 total points in two home games despite facing Tony Romo and Aaron Rodgers. This is my makeup call after picking against Seattle in Carolina. I am saying there's a chance. Sando's best guess: Seahawks 20, Patriots 17

  • Buffalo Bills at Arizona Cardinals, 4:05 p.m. ET: The Cardinals, like the Rams, have had a few extra days to prepare. They've won eight in a row at home, which is easy to forget after a defeat as ugly as the one Arizona suffered in the Edward Jones Dome last week. Let's consider a hypothetical here. Let's say the Cardinals, coming off that rough game at St. Louis, had been given their choice of NFL opponents for Week 6. Would they have chosen any team other than the Bills? Sando's best guess: Cardinals 23, Bills 17.

  • New York Giants at San Francisco 49ers, 4:25 ET: Third down defined these teams during the NFC Championship Game. The 49ers weren't good enough on either side of the ball during that game. Still, the Giants needed special-teams gifts to prevail. I'm expecting the 49ers to play a cleaner game this week. Their offense is playing better than it was last season. That should be the difference. Sando's best guess: 49ers 24, Giants 17.

Note: We've also got the "You called it" competition going, plus the Pigskin Pick'em group.