Biggest Week 10 NFL questions, stats and predictions

Taking a spin around the NFL to get you ready for Week 10:

The big questions

Can the Seattle Seahawks' defense slow Tom Brady and the New England Patriots?

In a rematch of Super Bowl XLIX on Sunday night, the Seahawks will look to be the first team to keep New England's offense in check since Brady's return.

The Patriots' offense has averaged a league-best 33.0 points per game since Week 5 and is catching the Seahawks at a good time. Seattle has given up 50 points in its past two games and has allowed opponents to score on 10 of the past 16 possessions.

Of particular concern is third down. The Seahawks rank 26th in third-down defense and have played 244 snaps the past three weeks -- more than any other defense in the NFL. Meanwhile, Brady is 27-for-35 (77.1 percent) for 505 yards (14.43 YPA), five touchdowns and no interceptions on third down.

The Seahawks will get strong safety Kam Chancellor back for this game but will be without defensive end Michael Bennett, who is recovering from knee surgery.

The Patriots go into this matchup as 7.5-point favorites.

Can the Pittsburgh Steelers end the Dallas Cowboys' win streak?

The Cowboys have won seven straight games and are the hottest team in the NFL. They haven't lost since the opener, and their plus-83 point differential is second to that of the Patriots.

Dallas continues to use the same formula for success: string together long drives on offense and limit what the defense is asked to do. The Cowboys are averaging 6.65 plays per drive. If that were to hold up, it'd be the highest average for any offense the past three seasons. Their defense, which has clearly outperformed expectations, is averaging just 60.25 snaps per game, which is third-fewest.

The Steelers got Ben Roethlisberger back last week but haven't won a game since Oct. 9. Pittsburgh is a 2.5-point favorite at home.

Can the Denver Broncos keep up with Drew Brees and the New Orleans Saints?

After an 0-3 start, the Saints have won four of their past five. At 37, Brees is on pace for 5,376 yards, 42 touchdowns and 10 interceptions.

The Broncos have the second-best pass defense in the NFL, according to Football Outsiders, but will be playing without cornerback Aqib Talib.

One thing to keep an eye on in this game is how each offense handles the blitz. The Broncos' and Saints' defenses rank first and second in blitz frequency, at 38.9 percent and 38.2 percent. Trevor Siemian and Brees rank ninth and 14th, respectively, in QBR against the blitz so far this season.

The Saints are 3-point favorites at home.

Numbers that matter

19.5: The percentage of Washington Redskins drives that have ended without a first down or touchdown. That's the lowest percentage of any offense in the NFL. The Redskins have punted 26.4 percent of the time, which is second-lowest after the Atlanta Falcons. Washington's problem has been finishing. The offense has scored touchdowns on 40.6 percent of its red zone trips, which is third-worst. If the Redskins can get that number up, they'll be one of the more prolific offenses in the league in the second half of the season.

95.6: Ryan Tannehill's QBR against the blitz, which is second-highest in the NFL behind Brady's. Tannehill is 37-for-54 (68.5 percent) for 730 yards (13.52 YPA), three touchdowns and no interceptions when defenses send five or more pass-rushers his way.

32nd: Case Keenum's rank in total QBR. He has thrown nine touchdown passes and 11 interceptions in eight games and has a passer rating of 77.2 (29th). Jeff Fisher told reporters that Keenum gives the Rams the best chance to beat the New York Jets and said the team will continue to be patient with Jared Goff because "the quarterback position is not easy."

What we'll be talking about after Week 10

Matt Ryan against the Philadelphia Eagles' pass rush: According to Football Outsiders, this game pits the NFL's most efficient offense (the Atlanta Falcons) against the most efficient defense (the Eagles). For Philadelphia to avoid a three-game losing streak and have a chance of slowing Ryan, its pass rush needs to dominate. The Eagles are producing sacks on 7.5 percent of their opponents' dropbacks, which is fourth-best.

The Carolina Panthers' relevance: They've won two in a row and are 3-point favorites at home against the Kansas City Chiefs. The front seven has been the difference. The Panthers have totaled 12 sacks in the past two games, more than any other defense in the NFL. With a win Sunday, they'd improve to 4-5 before a big Thursday night matchup against the Saints.

Brock Osweiler's continuing struggles: He's averaging 5.79 yards per attempt, which is last in the NFL, and has been particularly bad on throws downfield. According to ESPN Stats & Information, Osweiler has completed just 37.4 percent of his attempts that have traveled 10 yards or more past the line of scrimmage. That's the worst mark in the league. The Houston Texans are 2.5-point underdogs on the road against the 2-6 Jacksonville Jaguars.