1 p.m. ET | CBS
Matchup rating: 50.5 | Spread: TB -7.5 (44.5)
What to watch for: The 22-year-old Justin Herbert and the 43-year-old Tom Brady face off in what will be the first game since at least 1950 that two opposing quarterbacks have a 20-year age gap. But this is really about a Bucs' pass-rush that has 12 sacks through the first three games of the season -- its best mark since 2013 -- against a rookie quarterback who's handling the blitz remarkably well. How will Herbert fare with offensive linemen Bryan Bulaga and Trai Turner both battling injuries? -- Jenna Laine
Bold prediction: Herbert will have his best day of his young career as an NFL quarterback, throwing for more than 400 yards. The Chargers will regroup and reload on defense, too, leading to a big victory on the road. -- Shelley Smith
Stat to know: Herbert is just the third player in NFL history to pass for 300-plus yards in each of his first two career games, joining Kyler Murray and Cam Newton. Brady, however, now has eight consecutive games with under 300 passing yards.
Betting nugget: Brady has won eight straight meetings against the Chargers, going 7-1 ATS in that span. Read more.
Smith's pick: Chargers 34, Buccaneers 27
Laine's pick: Buccaneers 28, Chargers 13
FPI prediction: TB, 78.4% (by an average of 10.9 points)
Matchup must-reads: Keys to Chargers turnaround? 'Eliminating the stupid and the turnovers' ... WR Godwin likely out vs. Chargers; Week 6 return possible ... What's going right for the Bucs' suddenly potent pass rush? ... Gronk on Brady: Hard to believe he's 43 years old