4:05 p.m. ET | FOX
Matchup rating: 47.3 | Spread: LAR -13 (47)
What to watch for: The Giants are really struggling amid an 0-3 start, scoring an average of only 12.3 points per game. The Rams offense, however, is finding its stride behind quarterback Jared Goff and is unlikely to slow down against a defense that's allowing 26.3 points per game. Watch for the Rams' running game to get moving behind Darrell Henderson Jr. and for Goff to establish early connections with a plethora of targets with Giants defensive back Jabrill Peppers unlikely to play because of an ankle injury. -- Lindsey Thiry
Bold prediction: Aaron Donald produces double-digit QB pressures. He's done it before (Week 1 against the Cowboys), so why not again against this Giants offensive line which allowed seven to Bud Dupree in Week 1 and seven to Khalil Mack in Week 2? Donald versus Nick Gates, who was moved to center this season, is a massive mismatch. -- Jordan Raanan
Stat to know: The Giants have an NFL-worst 170 rushing yards this season, the fifth-least total though three games in franchise history. On the other side of the field, the Rams' Henderson is coming off a career-high 114 rushing yards last week, and Los Angeles has six TDs on the ground this season (only the Patriots have more this season with seven).
What to know for fantasy: Henderson is averaging 6.1 yards per carry over the past two weeks with a rushing score in both of those games. See Week 4 rankings.
Betting nugget: Three of the last four times New York has been a double-digit underdog, it won the game outright, dating back to its Super Bowl XLII win over New England. Read more.
Raanan's pick: Rams 31, Giants 20
Thiry's pick: Rams 35, Giants 14
FPI prediction: LAR, 84.8% (by an average of 14.2 points)
Matchup must-reads: Giants preach optimism, but they're not close to being a good team ... The Rams extended Ramsey, Kupp and Woods: Now what? ... Projected 2021 NFL draft order: Giants, Jets take over as favorites for No. 1 pick ... Rams decry costly pass interference call that led to Bills' go-ahead TD