1 p.m. ET | CBS
Matchup rating: 24.9 | Spread: PHI -6 (46.5)
What to watch for: This game will be decided based on whether the Eagles can generate a pass rush. Rookie Bengals QB Joe Burrow has been sacked six times this season, tied for the fifth-most in the NFL, while the Eagles defense ranks toward the bottom of the league with four sacks generated. With defensive tackle Fletcher Cox (oblique) ailing, the pressure falls to players like Brandon Graham and Malik Jackson to turn up the heat. -- Tim McManus
Bold prediction: Eagles running back Miles Sanders will rush for at least 150 yards. The Bengals' run defense has been woeful through the first two weeks of the season. With defensive tackles Geno Atkins and Mike Daniels potentially out for another week, Sanders could be in for a big day. -- Ben Baby
Stat to know: Philadelphia quarterback Carson Wentz has struggled with accuracy this season. He's completing just 58.8% of his passes, well below his expected completion percentage of 67.7%, according to NFL Next Gen Stats. That's the second-worst completion percentage over expectation (minus-8.8%) in the NFL, according to NFL Next Gen Stats, behind Dwayne Haskins (10.6%). And after throwing multiple interceptions two times all of last season, Wentz has thrown two in each of his first two games this year. No Eagles QB has done so in three straight games since Ron Jaworski in 1985.
What to know for fantasy: Burrow's 61 pass attempts were the highlight of Thursday Night Football in Week 2, but don't overlook his 15 rushing attempts this season (fifth most among QBs). See Week 3 rankings.
Betting nugget: The Bengals are 13-0 ATS all-time against the Eagles. Read more.
Baby's pick: Eagles 27, Bengals 21
McManus' pick: Eagles 30, Bengals 20
FPI prediction: PHI, 60.4% (by an average of 3.7 points)