Sunday, 1 p.m. ET | CBS
Matchup rating: 73.6 | Spread: IND -1.5 (44.5)
What to watch for: The Steelers haven't had a balanced offense in weeks, and reinvigorating the run game will be especially difficult against a Colts defense that has stymied opponents on the ground. James Conner missed the loss to the Bengals with a quad injury, but Benny Snell played decently in his absence. If the Steelers' ground game continues to be absent, they'll need a much better performance from Ben Roethlisberger to pull out of a three-game slump. -- Brooke Pryor
Bold prediction: Steelers wide receiver JuJu Smith-Schuster said this week that he's done dancing on opponents' logos during pregame warm-ups, and even though this game is in Pittsburgh, that new mindset will pay off. He'll put up his first 100-yard receiving game since Oct. 28, 2019, and second since Dec. 23, 2018. -- Mike Wells
Stat to know: The Steelers have been held under 20 points in four consecutive games, their longest single-season streak since 2004, Roethlisberger's rookie year. They haven't been held under 20 points in five consecutive games in a single season since 1969 (six in a row). They lost their last 13 games in '69 to finish 1-13.
Playoff/draft picture: The Colts can clinch a playoff berth with a win and a loss by either the Ravens or Dolphins. The Steelers have already clinched a playoff spot, but they could clinch the AFC North title with a win over Indianapolis.
What to know for fantasy: Jonathan Taylor scored 15 fantasy points in just three of his first nine career games, but he has gone over that number in four straight (22 PPG over that stretch). See Week 16 rankings.
Betting nugget: Pittsburgh has failed to cover four straight games and is 0-3 ATS on short rest this season. Read more.
Wells' pick: Colts 21, Steelers 17
Pryor's pick: Colts 23, Steelers 17
FPI prediction: PIT, 64.5% (by an average of 4.9 points)
Matchup must-reads: Confidence grows for Jonathan Taylor as he carries Colts toward playoffs ... Steelers' Mike Tomlin plans to talk to JuJu Smith-Schuster about logo dancing antics ... In-game pressure brings out best in Colts' opportunistic defense ... Roethlisberger: Playing 'like poo,' must be better