What it means: Starting units played the first half and the 49ers' starting offense, the right side of the offensive line in particular, is in bad shape. The 49ers' starting defense, with NaVorro Bowman and his two sacks and cornerback Kenneth Acker and his end zone interception of Peyton Manning, looks in better shape.
Play of the game: Reggie Bush, appearing in a preseason game for the Niners for the first time, broke off a 21-yard run -- between the tackles -- on an inside handoff on a zone-read play and showed he still has burst. The play came on a third-and-22 situation, though.
Stat of note: At halftime, the 49ers had zero yards passing -- ZERO! -- because while Colin Kaepernick was 2-of-5 passing for 13 yards (he did not complete a pass until there were 38 seconds remaining in the half), his sacks wiped out the team passing yards.
Injuries of note: The really only uh-oh moment came when receiver Torrey Smith appeared to jam his left ring finger into the ground attempting to haul in a Kaepernick pass. A close-up shot showed that Smith already had the finger taped, too.
What’s next: The Niners have a short week in that they close out the preseason with a home exhibition against the San Diego Chargers on Thursday night. Hard to see the starters getting much, if any, playing time, even with rosters being reduced from 90 players to 75 on Tuesday.