Entering Sunday's game, the Cowboys had 4,105 offensive plays since the start of the 2011 season.
Romo and wide receiver Dez Bryant, now both out with injuries, were both off the field for 73 of those plays, or less than 2 percent of the team's offensive snaps.
The Cowboys are 6-9 when a quarterback other than Romo starts for them since Week 8 of 2006. Jon Kitna makes up nine of those games (the Cowboys were 4-5 in his starts). Brandon Weeden started one, lost, and had a 7.4 Total QBR.
Romo previously suffered the same injury in Week 7 of the 2010 season and did not play the rest of the season. Aaron Rodgers broke his clavicle in Week 9 of 2013. He missed seven weeks.
When Weeden starts in Week 3 it will be the third straight season that the Cowboys used multiple starting quarterbacks, all due to Tony Romo's injuries.
It's the first time Dallas will use multiple starting quarterbacks in three straight years since they did so in five straight seasons from 1998 through 2002.
Weeden has the lowest Total QBR of any quarterback since the start of the 2012 season (26.2)
But on the bright side for the Cowboys, Weeden went 7-of-7 in relief of an injured Tony Romo Sunday. In his Cowboys career, Weeden is now 29-of-36 (80.6 percent) targeting all players NOT named Dez Bryant. Bryant caught only 2 of 12 targets from Weeden last season.