Whitehurst took over for Jake Locker in the second quarter against the Jets, and while he threw for 203 yards, he could not guide the Titans to a touchdown.
With Zach Mettenberger out and Locker now on injured reserve, the Titans will turn to Whitehurst to start Thursday night in Jacksonville.
Whitehurst was the starter for the first game against the Jaguars, in Nashville on Oct. 12, when Sammie Hill got a hand on a last-second field goal attempt by Josh Scobee and preserved a 16-14 win for Tennessee.
The Titans haven’t won since then.
Whitehurst is sure to lean on tight end Delanie Walker, the player he’s thrown to the most in the five games he’s played in this season.
The Titans' third-string QB has hit Walker on 15 of 24 attempts this season for 235 yards. Kendall Wright, who has missed the last two games with a broken bone in his hand, is second for Whitehurst, with 15 catches on 21 attempts for 159 yards.
While Mettenberger is a downfield thrower, Whitehurst actually leads the Titans in yards per attempt this season at 7.93.
Whitehurst could also get an upgraded offensive line, as the Titans are hopeful left tackle Taylor Lewan and right tackle Byron Stingily will return Thursday night. Lewan has missed the last three games with a high ankle sprain, and Will Svitek has been struggling in his place. Stingily missed last week with an ankle injury of his own.
Jamon Meredith was signed a week ago and started for Stingily against the Jets.