1 p.m. ET | CBS
Matchup rating: 35.6 | Spread: TEN -9 (42)
What to watch for: Titans running back Derrick Henry has terrorized the Jaguars to the tune of 498 rushing yards in his last four games against them. Jacksonville added middle linebacker Joe Schobert in the offseason, allowing Myles Jack to move to his more natural weakside linebacker spot. Pay attention to how the Titans find ways to get Henry to the second level of the defense, and how Jacksonville's linebackers attempt to prevent explosive plays. -- Turron Davenport
Bold prediction: Henry doesn't hit 100 yards rushing. He has rushed for 238 yards and 159 yards in the last two meetings in Nashville, and he has seven 100-plus-yard rushing games since the start of the 2019 season (tied for the most), but the Jaguars' run defense did a good job against the Colts for the final two and a half quarters last Sunday, and rookie defensive tackle DaVon Hamilton played well in his debut. The Jaguars are making Henry their top priority -- they might get hurt by the pass game, but they're not going to let Henry beat them again. -- Mike DiRocco
Stat to know: Jaguars quarterback Gardner Minshew II has three passing touchdowns in consecutive games dating to last year, and no QB in Jaguars history has thrown at least three in three consecutive games.
What to know for fantasy: Henry has seven rushing scores over his past three games against the Jags, and the Titans sure weren't shy about handing him the rock in Week 1 (31 carries, the only player in the NFL with more than 25). See Week 2 rankings.
Betting nugget: The Titans have covered five of their last six against the Jaguars. Read more.
DiRocco's pick: Titans 17, Jaguars 16
Davenport's pick: Titans 20, Jaguars 14
FPI prediction: TEN, 72.4% (by an average of 8.5 points)
Matchup must-reads: Jaguars can show Week 1 wasn't a fluke with victory at Tennessee ... Jaguars' Henderson thinks great debut could have been even better ... Titans' Byard can share home-birth story with his son 'for the rest of our days' ... Minshew and rookies come up big in upset ... Fourth-quarter comebacks becoming routine for Tannehill, Titans