1 p.m. ET | CBS
Matchup rating: 50.3 | Spread: TEN -3.5 (53.5)
What to watch for: The Titans will be creative in finding ways to pressure Texans quarterback Deshaun Watson. Tennessee coach Mike Vrabel was very aggressive last time out, sending defensive backs on the blitz. The Titans will also have Jeffery Simmons back to team up with Jadeveon Clowney on the inside, with Vic Beasley Jr. and Harold Landry III coming off the edge in their NASCAR package. They'll have to be disciplined and keep Watson from extending plays and finding his speedy receivers down the field. -- Turron Davenport
Bold prediction: Titans defensive lineman Clowney will get his first sack of the season against his former team. Clowney didn't get to face the Texans after they traded him to the Seahawks just before the 2019 season. His former defensive coordinator, Texans interim head coach Romeo Crennel, called the former No. 1 overall pick "a very disruptive player," adding, "I expect a great game from him, and he's going to try to play his best." Watson has already been sacked 17 times, third most in the NFL. -- Sarah Barshop
Stat to know: With Ryan Tannehill starting at quarterback, the Titans are 11-3 (.714) and have averaged 30.4 points per game. That's the best win percentage (minimum 10 starts) and most team points per game for a Titans/Oilers QB since the 1970 merger.
Betting nugget: Tennessee is 3-11 ATS in games that follow fewer than six days' rest since the start of the 2013 season. Read more.
Barshop's pick: Titans 31, Texans 21
Davenport's pick: Titans 34, Texans 20
FPI prediction: TEN, 61.8% (by an average of 4.2 points)
Matchup must-reads: Cooks enjoys a breakthrough with Watson ... Titans have been dominating in the red zone behind Tannehill ... McKinney expected out for season ... Unhappy LB Correa traded by Titans to Jaguars ... Texans hire search firm to assist GM search