This week, ESPN betting analysts Anita Marks and Doug Kezirian, along with ESPN Stats & Information's Mackenzie Kraemer and Seth Walder offer up their best bets.
Odds courtesy of Caesars Sportsbook as of Sunday, unless otherwise noted.
New England Patriots at Buffalo Bills (-2.5, 41.5)
Kraemer: According to FPI, the Bills are the best team in the NFL, and are 8.2 points better vs. an average opponent on a neutral field. There aren't many opportunities to get the best team in the NFL (on paper) laying less than a field goal at home, but because of the Patriots' recent hot streak, we have a spot here. New England has won and covered six straight, but the strength of schedule has been very weak. The Bills are a major step up in competition.
On a cold and windy day, one narrative is that the Patriots have the better running game, which is true. However, the Bills have the NFL's third-best run defense (according to EPA), while New England is 18th in that category.