The Tar Heels (32-7) advanced to their second straight national championship game by holding off Oregon 77-76 on Saturday. North Carolina was also a 2-point favorite over Villanova in last year's championship game. The Wildcats defeated the Tar Heels 77-74 on a buzzer-beating 3-pointer.
If the point spread holds with North Carolina as the favorite, Monday's game will be the first all season in which Gonzaga (37-1) has been the underdog.
The Tar Heels' win over Oregon on Saturday was big for a bettor at the South Point Casino, who risked $525,000 to win $250,000 on North Carolina to beat the Ducks straight up.
The over/under on Monday's championship game opened at 154.5 at most Las Vegas sportsbooks.