No. 2 Cincinnati Bearcats (-23.5, 58) at South Florida Bulls, 6 ET on ESPN2
USF has covered four straight games against ranked opponents, including 3-0 ATS this season.
USF has covered four straight as a home underdog, including 3-0 ATS this season.
Cincinnati has failed to cover six straight meetings, including 0-4 ATS under Luke Fickell (since 2017).
Cincinnati has failed to cover three straight (all as a favorite of 20+ points) following a 5-1 ATS start this season.
Cincinnati is 5-1 ATS in games off fewer than six days rest under Fickell.
The under is 18-7 in Cincinnati road games under Fickell, including three straight.
New Mexico State Aggies at No. 3 Alabama Crimson Tide (-51.5, 67), Noon ET
This would be the eighth instance since 2000 of a 50-point spread between two FBS teams. Alabama was involved in two of the previous seven, including as 55-point favorites against New Mexico State in 2019 (failed to cover in 62-10 win). Overall, favorites of 50 or more points in FBS matchups are 7-16 ATS since the 1978 FBS/FCS split, including 3-13 ATS since 1990 and 1-6 ATS since 2000.
New Mexico State is 5-0 ATS in road games this season, all as an underdog.
New Mexico State is 6-1 ATS following a loss this season.
Alabama is 8-1 ATS as a home favorite since the start of last season.
New Mexico State has failed to cover 11 of its last 15 games against ranked opponents, including 2-5 ATS under Doug Martin (since 2013).
New Mexico State is 10-17-2 ATS in games in November or later under Martin.
Alabama is 4-10 ATS as a favorite of 45 or more points under Nick Saban (since 2007).
No. 9 Michigan Wolverines at No. 23 Penn State Nittany Lions (Even, 48.5), Noon ET on ABC
The over is 19-11 in Michigan road games under Jim Harbaugh, including 9-2 since 2019 and 6 straight.
Penn State is 5-1 ATS against teams with winning records this season.
Michigan is 7-2 ATS this season, tied for the third-best cover percentage in FBS.
Michigan is 4-1 ATS when the line is between -3 and +3 since 2019.
Penn State is 2-12 outright against AP Top-10 teams under James Franklin (since 2014).
Michigan is 1-4 ATS in games in November or later since 2020.
No. 4 Oklahoma Sooners (-5.5, 62.5) at No. 18 Baylor Bears, Noon ET
Baylor is 5-0 ATS in home games this season. The Bears are one of five remaining teams without an ATS loss at home.
Oklahoma is 12-6-1 ATS against ranked opponents under Lincoln Riley (since 2017), including 5 straight covers dating to last season.
Oklahoma is 1-4 ATS under Riley against Baylor.
Oklahoma is 5-11-1 ATS as a road favorite under Riley.
The over is 4-1 in Oklahoma's last 5 games (over was 2-2 in Oklahoma's first 4 games this season).
Mississippi State Bulldogs at No. 16 Auburn Tigers (-5.5, 50), Noon ET on ESPN
Mississippi State has covered 5 of its last 6 road games and 3 straight overall, regardless of venue.
Auburn has covered 12 of its last 15 games as a home favorite (3-1 ATS under Bryan Harsin this season).
Auburn has covered 7 of its last 8 games as a favorite, regardless of venue (includes 2 road games).
Mississippi State has covered 4 straight as a road underdog.
The under is 8-2 in Mississippi State games under Mike Leach following a loss (since 2020).
Mississippi State has covered 4 of its last 5 games against ranked opponents.
Northwestern Wildcats at No. 20 Wisconsin Badgers (-24, 41), Noon ET on ESPN2
Northwestern is 0-3 ATS in road games this season.
Northwestern has covered four straight meetings dating to 2017.
Wisconsin has covered three straight after starting the season 2-4 ATS.
Northwestern is 33-19 ATS as a road underdog under Pat Fitzgerald (since 2006), including 14-5 ATS since 2015. However, four of those five ATS losses have come since 2019.
Wisconsin has covered four straight conference games.
Northwestern is 7-1 ATS in games in November or later since the start of last season.
The under is 4-1 in Wisconsin home games this season.
Purdue Boilermakers at No. 6 Ohio State Buckeyes (-20, 62), 3:30 ET on ABC
Purdue is 7-1 ATS as a double-digit underdog under Jeff Brohm (since 2017), including five straight covers in such games.
The under is 4-0 in Purdue road games this season.
Purdue is 8-2 ATS as a road underdog under Brohm.
Purdue is 10-3 ATS against ranked opponents under Brohm, including 4-1 ATS against AP top 10 teams (three straight covers against AP top 10).
Ohio State is 13-6-1 ATS in conference games since 2019, Ryan Day's first full season as head coach (3-2-1 ATS this season).
The over is 8-2-1 in Ohio State games against conference opponents since the start of last season.
Ohio State is 4-9 ATS in games in November or later since 2019.
Maryland Terrapins at No. 8 Michigan State Spartans (-13, 62), 4 ET
Maryland is 3-9 ATS in road games under Mike Locksley (since 2019), including 0-3 ATS this season.
Maryland is 1-8 ATS against ranked opponents under Locksley. The Terrapins have failed to cover eight straight against ranked teams, the longest active streak in FBS.
Maryland has failed to cover five straight (four of five as underdog).
Michigan State is 2-12 ATS as a home favorite since 2018, including 1-3 ATS under Melvin Tucker (since 2020).
Michigan State is 3-10 ATS as a double-digit favorite since 2018 (1-1 ATS under Tucker).
Maryland has failed to cover eight straight conference games (0-6 ATS this season).
The total has gone under in six straight meetings.
No. 11 Texas A&M Aggies (-2.5, 55.5) at No. 12 Ole Miss Rebels, 7 ET on ESPN
Ole Miss is 0-3 ATS against ranked teams this season.
Texas A&M has covered four of its last five games against ranked opponents.
Texas A&M has covered eight straight games as a road favorite dating to 2017, the longest active streak in FBS (7-0 ATS under Jimbo Fisher).
Texas A&M has covered four straight games after starting the season 2-3 ATS.
The under is 5-1 in the Rebels' last six games after going 1-2 to start the season.
Six straight meetings have gone under the total dating to 2014.
Ole Miss is 3-10 ATS when the line is between -3 and +3 over the last five seasons, including 1-3 ATS under Lane Kiffin (since 2020).
No. 7 Notre Dame Fighting Irish (-5.5, 64.5) at Virginia Cavaliers, 7:30 ET on ABC
Notre Dame has covered six of its last seven games after starting the season 0-2 ATS.
Virginia is 4-1 ATS in home games this season.
Virginia is 13-3 ATS following a bye dating to 2010 (6-1 ATS since 2017, Bronco Mendenhall's second season as Cavaliers' head coach).
The over is 5-1 in Virginia games under Mendenhall (since 2016) against AP top-10 teams.
Notre Dame is 10-3 ATS in games in November or later since 2019.
No. 21 NC State Wolfpack at No. 13 Wake Forest Demon Deacons (-2, 66.5), 7:30 ET
Wake Forest is 14-5 ATS against ranked opponents under Dave Clawson (since 2014).
The total has gone under in five straight games involving Wake Forest against ranked opponents.
NC State is 4-1 ATS when the line is between -3 and +3 since the start of last season.
NC State has covered five of its last six games as an underdog.
NC State is 4-11 ATS in its last 15 road games.
NC State is 11-4 ATS in games against conference opponents since the start of last season.
Arkansas Razorbacks (-2.5, 59) at LSU Tigers, 7:30 ET
Arkansas has failed to cover six straight games as a road favorite dating to 2011, tied for the second-longest active streak in FBS with SMU. Florida (second straight) is the only team with a longer such active streak.
LSU is 12-5 ATS as an underdog since 2017, Ed Orgeron's first full season at the helm.
LSU hasn't lost three straight games outright since 2015. The Tigers have lost each of their previous two games (at No. 12 Ole Miss, at No. 3 Alabama).
Arkansas is 1-14 outright in road games since 2018, including 1-6 under Sam Pittman (since 2020).
LSU has won five straight meetings dating to 2016.
LSU is 16-7 ATS in games in November or later since 2017.
Washington State Cougars at No. 5 Oregon Ducks (-14, 56.5), 10:30 ET on ESPN
Oregon is 7-15-1 ATS as a double-digit favorite since 2018, Mario Cristobal's first full season at the helm. The Ducks have failed to cover seven straight games as a double-digit favorite, tied with UConn for the longest active streak in FBS.
Oregon is 4-14-1 ATS as a home favorite since 2018, including 0-5 ATS this season (all as a favorite).
Washington State is 5-1 ATS as an underdog this season, including 3-0 ATS on the road.
Oregon is 11-19-1 ATS as a favorite since 2018, including 1-9 ATS in its last 10 such games.
Washington State has covered six straight games.
Washington State has covered 10 of the last 11 meetings since 2010.
Washington State is 1-5 ATS against ranked opponents since 2019.