Notable bets: Behind the Bills-Chiefs and Cowboys-Eagles opening lines

Josh Allen and the Bills face the Chiefs in what could be an AFC Championship preview. William Purnell/Icon Sportswire

Patrick Mahomes begins the week in new territory: a home underdog for the first time in his career.

On Sunday afternoon, sportsbooks installed Mahomes and the Kansas City Chiefs as 2.5-point underdogs to the visiting Buffalo Bills in a Week 6 showdown that's expected to attract massive betting interest. If the line holds -- it was dropping Sunday night -- Mahomes will be a home underdog for the first time in his career.

Last week, sportsbook operator the SuperBook made the game a pick 'em. John Murray, executive director of the SuperBook, said the pick 'em line reflected the Bills being perceived as the better team while crediting the Chiefs for the impressive win over the Tampa Bay Buccaneers and factoring in some home-field advantage. But on Sunday, when the SuperBook reposted the line, Murray said they felt obligated to make the Bills the favorites.

"After seeing what the Bills did to the Steelers today [38-3 win], we knew we had to reopen the game with Buffalo favored," Murray said. "We took a few bets on Chiefs +2.5 but are leaving it there for now."

The line had dipped to Buffalo -2 at most sportsbooks Sunday night. The Chiefs host the Las Vegas Raiders on Monday Night Football.

Kansas City beat Buffalo 42-36 in an epic overtime thriller at Arrowhead Stadium in last season's playoffs. The game featured three lead changes in the final two minutes, with the Chiefs getting into field goal range on a three-play drive that lasted just seven seconds to force overtime with a field goal.

Murray anticipates betting support for both teams and a lot of money on the over, which opened at 54.

"Buffalo is such a complete team on both sides of the ball and very well coached," Murray added. "The Super Bowl is theirs to lose this season, and it really starts with this game. They win on Sunday and keep [quarterback Josh] Allen healthy, and they will very likely have home-field advantage in the AFC playoffs. This is the best game of the regular season."

The Chiefs are 6-2 outright as underdogs in Mahomes' starts.

Week 6 is also highlighted by the Dallas Cowboys' visit to the Philadelphia Eagles. The Eagles opened as 5.5-point home favorites, and the line was holding steady Sunday night. Dallas quarterback Dak Prescott has missed the past four games after injuring his thumb in an opening loss to the Buccaneers. Backup Cooper Rush has led the Cowboys to four straight wins in Prescott's absence.

Prescott says he's day-to-day, but oddsmakers aren't expecting him to play against the Eagles.

"At this point, I don't think there's much difference at all in the point spread if Dak goes [instead of Rush]," Murray told ESPN. "Dallas is winning with their defense, not their offense, and putting in a less-than-100% Dak could end up being a negative thing if they open up the playbook too much and start turning the ball over."

Adam Pullen, assistant director of trading for Caesars Sportsbook, believes the line would move a little toward the Cowboys if Prescott were cleared to play.

"Even with Rush's success, Prescott is still viewed as the better player," Pullen said. "I think the line would drop to at [Eagles] -3, maybe a little bit lower."

Six-figure score on no touchdowns

Thursday's 12-9 overtime thriller between the Indianapolis Colts and Denver Broncos featured no touchdowns but plenty of excitement for savvy bettors, who pinpointed a 100-1 long shot that they had to sweat all the way through the game's final play.

Betting on which player will score the game's first touchdown has emerged as one of the most popular ways to bet on the NFL at sportsbooks in the United States and the United Kingdom. Most weeks, the betting public loads up on a prolific pass-catcher, like Cooper Kupp, Travis Kelce or Stefon Diggs. But on Thursday, bettors took an alternate approach.

FanDuel offers "No Touchdown Scored" as an option in its odds to score the game's first touchdown. On Thursday, for the first time this season at FanDuel, no touchdown attracted more bets -- and more money wagered -- than any of the players listed. Broncos receiver Jerry Jeudy was the second-most-popular choice at FanDuel. Approximately 22% of the money wagered on the first touchdown odds were on no touchdown, including a $1,000 bet at 100-1 that paid a net $100,000.

"[It] was the first game all year to have no touchdown as the most popular selection [in the first-touchdown odds]," Kevin Hennessey, spokesperson for FanDuel, told ESPN. "It tends to always be a player."

Other sportsbooks had a much shorter price on no touchdowns being scored. Caesars Sportsbook, for example, offered only 35-1 on the prop, nothing that the over/under total on the game was only 41.5. Craig Murdock, director of trading for Caesars Sportsbook, said the lower odds helped the book avoid a big loss on the market.

"Sometimes, some of the best bets you take are the ones that you don't actually take," Murdock said.

The Colts came from behind to beat the Broncos, despite surrendering six sacks, throwing two interceptions and, of course, scoring no touchdowns.

NFL notables

• Most sportsbooks were reporting a winning Sunday, with the underdog New York Giants' outright upset of the Green Bay Packers in London getting the day off to a bad start for the betting public.

The Giants upset the Packers as 9-point underdogs Sunday in London. It's the largest upset point spread-wise of the season so far and the largest ever in a London game.

Upset wins by the New York Jets and Houston Texans, in addition to the Atlanta Falcons and Chicago Bears covering the spreads, bolstered the winning day for the sportsbooks.

"In general, it was a pretty good day, not really any huge losses," Pullen of Caesars Sportsbook said.

"Last week, we lost a little on a lot of games," Murdock added. "This week, we won a little on a lot of games."

• The Cardinals' covering the spread in a 20-17 loss to the Eagles resulted in the biggest loss of the day for sportsbook WynnBET. "We had a pretty good morning," Andy Morrissey, WynnBET trader, told ESPN on Sunday night. "The Cardinals' game hurt us. We had a large wager on the Cards' spread, so that swung the day for us. We are in the red as it stands going into Sunday Night Football."

The SuperBook also reported the Cardinals' covering as the book's worst decision of the day.

• Sportsbook PointsBet took a $2 bet on New Orleans Saints tight end Taysom Hill to score three touchdowns against the Seattle Seahawks at 175-1 odds. Hill rushed for three touchdowns in the Saints' win over Seattle, and the bettor won $350. Another bettor placed a $1 bet on Hill to score three touchdowns before the game but evidently had a change of heart and cashed out for their original stake before the game started.

• Week 16 opening lines (via the SuperBook at Westgate Las Vegas)
Commanders -1, 40 at Bears (Thursday)
Buccaneers -7.5, 44 at Steelers
Bengals at Saints pick 'em, 45
Jaguars at Colts pick 'em, 42
Patriots at Browns -3, 42
Jets at Packers -7,44
Vikings -3, 45.5 vs. Dolphins
49ers -4.5, 41.5 at Falcons
Panthers at Rams -9.5, 42
Cardinals -2.5, 49 at Seahawks
Bills -2.5, 54 at Chiefs
Cowboys at Eagles -5.5, 43.5
Broncos at Chargers -6.5, 46 (Monday)

$38,000 riding on a Aaron Judge at-bat

Bettors on DraftKings combined to bet approximately $262 million on small in-game events, like the result of a pitch or an at-bat during the Major League Baseball regular season, according to data released by odds-provider SimpleBet. The data represents only action at DraftKings.

According to the SimpleBet data:

• Forty percent of the money wagered -- roughly $105 million -- was on the result of individual pitches. SimpleBet posted odds on 715,000 individual pitch results. "Strike/foul ball" was the most popular choice, attracting approximately 60% of the pitch result wagers.

• More money was bet on the at-bats of New York Yankees slugger Aaron Judge than any other player. Judge accounted for approximately 150,000 of the at-bat micro-bets this season.

• $38,000 was bet on Judge's second at-bat on Sept. 28 against the Toronto Blue Jays, when he was sitting on 60 home runs.

MLB notables

• The Seattle Mariners, down seven runs to the Toronto Blue Jays on Saturday, were as long as 35-1 to come from behind and win at Caesars Sportsbook. The Mariners rallied back for a 10-9 win.

• Series prices for divisional round (via Caesars Sportsbook):

Phillies (+165) vs. Braves (-200)
Mariners (+210) vs. Astros (-260)
Guardians (+200) vs. Yankees (-250)

College football notables

• James Madison is the only FBS team to have covered the spread in each of its games this season. TCU and Kansas also are unbeaten against the spread but played to a push in the Horned Frogs' 7-point win over the Jayhawks on Saturday.

• Notable opening lines via Circa Sports:
Penn State at Michigan -7, 51.5
Alabama -8, 66.5 at Tennessee
Oklahoma State at TCU -2, 69.5
USC at Utah -4, 60.5