The Bulls updated Rose's status Saturday, one day after the former league MVP suffered the injury against the Portland Trail Blazers.
Rose underwent an MRI in Los Angeles on Saturday, a test that revealed a medial meniscus tear in his knee. The team confirmed Sunday that Rose will have surgery Monday in Chicago.
#Bulls coach Tom Thibodeau tells reporters that Derrick Rose's surgery will take place Monday in Chicago.
— Chicago Bulls (@chicagobulls) November 24, 2013
The three-time All-Star sat out last season recovering from a torn anterior cruciate ligament in his left knee. Now, it's his other knee that's injured.
The injury occurred in the third quarter against the Trail Blazers.
Rose lost his footing while trying to change direction to get back on defense when Nicolas Batum stole a pass from Joakim Noah and started the other way. Rose limped across the court and couldn't put any weight on his knee. After the Blazers scored, he came out of the game during a timeout.
It didn't appear there was any contact on the play. Rose was unable to return and was on crutches afterward. He will not accompany the Bulls for the remaining four games on their six-game trip.
The Bulls will face the Los Angeles Clippers Sunday without Rose.
"I feel bad for him," said Clippers forward Blake Griffin who suffered a meniscus tear in July 2012 during Olympic training. "You never want to see somebody go down. Obviously, I've experienced a couple of knee injuries, including the meniscus. The good news is that it's not nearly as bad as the one that he just went through. I wish him the best."
Even though the injury isn't as serious as a torn ACL, losing Rose for any chunk of time is obviously a huge blow for a team expecting to challenge LeBron James and the Miami Heat for supremacy in the Eastern Conference with its franchise player back.
Now, there's a big cloud hanging over the franchise. And once again, it centers on Rose.
The latest injury rekindled memories of the 2012 playoff opener against Philadelphia, when he crumpled to the court near the end of the game with a torn ACL in his left knee. That sent the top-seeded Bulls toward a first-round exit and put them in a holding pattern last season while their star recuperated.
Many thought he would return at some point, particularly after he started practicing without restrictions. Instead, his recovery took on almost a circus-like feel.
Fans saw him shooting and dunking before games last season and wondered why he wasn't playing. Meanwhile, the Bulls fought injuries and illnesses on the way to 45 wins and a first-round playoff victory over Brooklyn before falling to Miami.
Along the way, his image took a hit.
Adidas released videos documenting his progress, but Rose mostly stayed in the background, saying little about his recovery. That changed midway through the season.
There was also speculation of a rift with the organization after older brother Reggie Rose ripped management for standing pat at the trade deadline, but Derrick Rose denied that.
All those issues faded into the background with Rose back this season. He had insisted he was returning better than ever, had no doubts he would regain his MVP form, but he was off to an up-and-down start after a dominant preseason.
A sore hamstring caused him to miss a game, and he is shooting just 35.4 percent. He was looking better the past two games, with 19 points in a loss at Denver and 20 against Portland.
Information from ESPNChicago.com's Nick Friedell, ESPN.com's Kevin Arnovitz and The Associated Press was used in this report.