The Blue Devils (2-2) surpassed their previous scoring average of 18.3 points per game with 21 in the first quarter, when Thompson rushed for both of his touchdowns.
Quarterback Sean Renfree completed 21 of 30 passes for 278 yards and a touchdown for the Blue Devils. His 7-yard scramble late in the third quarter gave Duke a 45-13 lead.
Duke outgained the Green Wave (2-2) 336 yards to 127 in the first half. The only touchdown until the fourth quarter for Tulane, which scored 49 points last week in a win over UAB, came on Ryan Travis' 23-yard interception return in the first quarter.
Duke's defense, which shut out Boston College in the second half of a 20-19 win last week, had put together a streak of five quarters without allowing a touchdown.
Power 5 conference revenues varied greatly for 2020-21 season amid COVID-19 pandemic
Power 5 conference revenues varied greatly during the 2020-21 season, largely because of the COVID-19 pandemic.
College football spring transfer tracker: Top players in the portal, big moves and analysis
Who are the best college football players who have entered -- and exited -- the transfer portal during the second wave?
Mountain West Conference to eliminate football divisions in 2023
The Mountain West has followed the Pac-12 with its move to scrap divisions after the NCAA Division I Council relaxed restrictions on college football conference championship games.
Calvin Magee, Jacksonville State assistant head football coach, dies at age 59
Calvin Magee, Jacksonville State assistant head football coach, died after suffering a heart attack last weekend, the school announced Friday. He was 59.
Acho: Hunter picking an HBCU was never about money
Sam Acho reacts to Nick Saban's comments about Jackson State and why Travis Hunter chose a historically Black university over other programs.
History of Saban and Jimbo going toe-to-toe
Take a look back at the rising tensions over the years in the SEC between Nick Saban and Jimbo Fisher.