Eastern Illinois (1-0) snapped a 19-19 tie when Taylor Duncan capped a 12-play 75-yard drive with a two-yard TD run with 7:36 left in the third quarter.
Duncan, who rushed for 94 yards on 20 carries, would cap the night with a 45-yard TD run with 4:40 left.
Eastern Illinois built a 19-13 lead at halftime as Garoppolo completed 15 of 24 passes for 246 yards and threw touchdown passes of 37 and four yards to Lora and a 62-yard strike to Keiondre Gober that snapped a 13-13 tie with 3:22 left in the first half.
Lora caught 10 passes for 87 yards.
San Diego State (0-1) got a 48-yard touchdown run from Colin Lockett in the first quarter.
College football today - Week 4 updates, highlights, biggest moments and more
Here are the best moments on and off the field from college football's Week 4.
Louisville Cardinals LB Monty Montgomery out for season with torn ACL
Louisville starting linebacker Monty Montgomery will miss the rest of the season with a torn ACL in his right knee, the school announced Saturday hours before kickoff against Florida State.
Tebow believes Corral is leading the Heisman race
SEC Nation's Tim Tebow and Jordan Rodgers discuss the productive play from quarterbacks Matt Corral and Bryce young and who's leading the Heisman race.
Tre Turner's impressive TD grab puts Virginia Tech on the board
Tre Turner makes the snag and gets his foot down in the end zone to put VT up 7-0.
Miami Hurricanes quarterback D'Eriq King out vs. Central Connecticut due to shoulder injury
Miami quarterback D'Eriq King won't play against Central Connecticut on Saturday because of a shoulder injury, while starting safety Gurvan Hall Jr. will also sit out while serving a one-game suspension.
Corso's pick: Notre Dame vs. Wisconsin
Lee Corso makes his headgear pick for No. 12 Notre Dame vs. No. 18 Wisconsin.