STATE COLLEGE, Pa. -- Sean Clifford turned in an all-around performance in another lopsided win for Penn State.
Clifford threw for 280 yards and four touchdowns and ran 11 times for 51 to lead the No. 15 Nittany Lions back from a halftime deficit to beat Buffalo 45-13 on Saturday night.
"Sean's able to make plays with his mind, he's able to make plays with his arm and tonight he made plays with his feet as well," coach James Franklin said.
Clifford, the Lions' first-year starter, opened the scoring with a 28-yard pass to Jahan Dotson on Penn State's second drive. He tossed a pair of TDs to tight end Pat Freiermuth in the third quarter after cornerback John Reid's 37-yard interception return put Penn State up for good.
Noah Cain added a 2-yard TD run to give Penn State's a 35-13 lead heading into the fourth.
"We weren't executing in the first half," Clifford said. "I take the blame for that. We pulled together and talked through some things and got it going in the second."
The Nittany Lions (2-0) trailed 10-7 at half after the Bulls (1-1) had dominated time of possession to that point.
"They played really hard, competed really well for the first 30 minutes," Buffalo coach Lance Leipold said. "Came out in the second half and, obviously, a big switch in momentum."
Jaret Patterson led Buffalo (1-1) with 75 yards on 23 carries while Myers finished 16 for 31 for 236 yards.
Franklin called Reid's interception the turning point in the game. Players along Penn State's sideline erupted when the fifth-year senior stepped in front of Antonio Nunn's route, snagged Myers' underthrown pass and sprinted untouched down the sideline.
It was the second straight game with an interception for Reid who's just over two years removed from a serious knee injury that cost him all of 2017.
"It was huge," Clifford said. "For us, on offense, we feed off that energy. The crowd gets back into it."
RETURN TO FORM
Freiermuth, arguably Penn State's most dangerous red zone target, finished with eight catches for 99 yards a week after he was knocked out of the game against Idaho with an apparent head injury.
Freiermuth, who led the team with eight touchdown catches last year, missed some practice time this week to heal up.
Buffalo punter Evan Finegan was carted off after suffering what appeared to be a serious right leg injury following a partially blocked punt in the third quarter. Reserve quarterback Kyle Vantrease handled punting duties the rest of the way.
Buffalo: The daunting environment didn't seem to bother the young Bulls. They controlled the pace in the first half, running 46 plays for 27 yards to Penn State's 20 plays and 82 yards.
Penn State: The Nittany Lions' strength is their defensive line and Buffalo's offensive front did a good job neutralizing Yetur Gross-Matos and his teammates for most of the first half. In the meantime, Clifford and his receivers were able to create some chemistry.
Penn State cleaned up its mistakes at halftime, won going away and shouldn't be penalized for its slow start.
Buffalo plays at Liberty Saturday.
Penn State hosts Pittsburgh Saturday.
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