Eastern Illinois (1-0) snapped a 19-19 tie when Taylor Duncan capped a 12-play 75-yard drive with a two-yard TD run with 7:36 left in the third quarter.
Duncan, who rushed for 94 yards on 20 carries, would cap the night with a 45-yard TD run with 4:40 left.
Eastern Illinois built a 19-13 lead at halftime as Garoppolo completed 15 of 24 passes for 246 yards and threw touchdown passes of 37 and four yards to Lora and a 62-yard strike to Keiondre Gober that snapped a 13-13 tie with 3:22 left in the first half.
Lora caught 10 passes for 87 yards.
San Diego State (0-1) got a 48-yard touchdown run from Colin Lockett in the first quarter.
Virginia Tech looks to start homestand with win vs Richmond
Virginia Tech is looking to begin a four-game homestand looking with a win when the Hokies play Richmond for the first time since 1986.
Minnesota's shutout-emboldened 'D' pivots to Bowling Green
— After a troubling amount of long-gain lapses in the first two games of the season following a rough 2020, Minnesota's defense needed a change in mindset.
Arizona St, Colorado try to shake mistakes in Pac-12 opener
— Arizona State's offense has had a problem with moving backward. The issue for Colorado is its offense isn't moving much at all.
Virginia looks to rebound vs Wake Forest after tough loss
Virginia is eager to get back on the field after allowing 59 points and 699 yards in a 59-39 loss against No. 21 North Carolina.
Cal and Washington meet for 100th time to open Pac-12 play
— California coach Justin Wilcox and Washington coach Jimmy Lake both finished off the nonconference portion of their schedules with major unknowns.
No. 23 Auburn seeking to rebound against Georgia State
The Auburn Tigers are hoping to once again enjoy the comforts of home as heavy favorites.