Mauk added another 75 yards on the ground, picking up four first downs, and completed 10 consecutive passes in the first half, including a 26-yard toss to a streaking Sasser in the end zone over defender J.D. Harmon.
Sasser also hauled in a 3-yard toss for a TD and finished with six catches for 67 yards. Andrew Baggett kicked 41- and 21-yard field goals.
Coupled with Georgia's 38-20 loss to Florida, the Tigers (7-2, 4-1) now lead the Southeastern Conference Eastern Division by a half-game.
Missouri's offensive struggles reappeared at times as the Tigers gained 320 yards, but the defense limited Kentucky to 258 yards and 2-for-16 on third-down conversions.
Patrick Towles gained 158 yards through the air for Kentucky (5-4, 2-4), a week after throwing for a career-high 390 yards against Mississippi State.
Kentucky struggled to achieve much consistency on offense itself, starting 0-for-8 on third-down conversions. Towles threw for 1 yard and an interception in the first half before leading an 80-yard touchdown drive to narrow his team's deficit to 20-10 with 3:26 remaining.
After a 3-and-out by Missouri, Kentucky had another chance but Shane Ray sacked Towles on 4th down, his second sack of the game and his 12th of the season, breaking the previous school record of 11.5 set by Aldon Smith and Michael Sam.
College football coaching carousel: Latest buzz, top candidates, analysis of every vacancy
From Notre Dame and Oklahoma to Washington and Virginia Tech, it's already been a wild ride on the coaching carousel. Here's everything you need to know.
Oklahoma finalizes deal with Brent Venables to be Sooners' football coach, sources say
Oklahoma has finalized a deal with Clemson defensive coordinator Brent Venables to be the Sooners' next football coach, sources said.
QB Michael Penix Jr. enters college transfer portal after 4 seasons with Indiana Hoosiers
Quarterback Michael Penix Jr. has entered the transfer portal after four injury-plagued seasons at Indiana.
New Florida Gators coach Billy Napier plans to hire 'unprecedented' support staff
New Gators coach Billy Napier outlined parts of his vision for Florida on Sunday, including plans to hire an "unprecedented" support staff.
What challenges will Bama face with Cincinnati?
The SEC Now crew discusses the CFP matchup between Alabama and Cincinnati, explaining where they think the Tide will struggle.
Former Oklahoma Sooners WR Jadon Haselwood transferring to Arkansas Razorbacks
Former Oklahoma receiver and top prospect Jadon Haselwood committed to Arkansas on Sunday after entering the transfer portal last week.