The first game will be in Norman on Sept. 6, 2025. The Sooners will return the trip Sept. 12 the following season.
"We are excited to reach an agreement to play Oklahoma, one of the storied programs in college football history," Michigan athletic director Dave Brandon said in a statement. "Oklahoma and Michigan have always been regarded as two of the top programs in college football, and creating this type of matchup is great for fans of both programs and the game of college football."
Despite their decorated histories, the Sooners and Wolverines have met only once before. Oklahoma defeated Michigan 14-6 in the 1976 Orange Bowl to clinch the program's fifth national championship.
"We remain committed to playing games that celebrate the history and excitement of college football," Oklahoma athletic director Joe Castiglione said in a statement. "Oklahoma and Michigan represent two of the most iconic names in American sport, and we look forward to a series that will be marked by mutual respect and admiration."