Fuller initially tore the meniscus in his knee during preseason camp but tried to play through it. He missed last week's game against East Carolina and was re-evaluated Monday, then had the surgery Tuesday.
"Kendall was very determined to compete as long as he could with this injury," coach Frank Beamer said in a statement. "While we are all disappointed that he is sidelined for the remainder of the season, we know Kendall will approach his rehab with a positive attitude and will continue to contribute to our team with his knowledge and leadership."
Virginia Tech must now move forward without its two most important players: Fuller and quarterback Michael Brewer, who continues to rehab from a broken collarbone suffered in the season opener against Ohio State.
Fuller, a preseason ESPN.com All-American, has a decision to make once the season ends. A junior, Fuller could forgo his senior season and enter the NFL draft.