Tuerk started 38 games in his career for the Trojans and was a first-team selection on the ESPN.com preseason All-American team. The injury occurred in the Trojans' 17-12 loss to Washington on Thursday.
After Tuerk left the game, sophomore Toa Lobendahn shifted from left guard to center and is expected to make his first career start at the position Saturday, when the Trojans play at No. 14 Notre Dame. Lobendahn has started games at tackle and guard during his short career.
USC also announced defensive end Claude Pelon is doubtful to play against the Irish due to a knee sprain, receiver Steven Mitchell Jr. is questionable with an ankle sprain and cornerback Iman Marshall is expected to play despite an issue with his abdomen.