Gone next season will be the team's leading rusher (Clyde Edwards-Helaire), leading pass-catcher (Justin Jefferson) and leading tackler (Jacob Phillips), as well as the nation's top defensive back, Jim Thorpe Award winner Grant Delpit.
The mass departure comes less than 24 hours after passing-game coordinator Joe Brady accepted the job as offensive coordinator for the Carolina Panthers.
Center Lloyd Cushenberry III, left tackle Saahdiq Charles and inside linebacker Patrick Queen announced their decisions to turn pro earlier Wednesday. ESPN's Mel Kiper ranks Cushenberry and Charles as top-10 prospects at their positions. Queen, who is not ranked among Kiper's top 10 at linebacker, finished with 85 tackles, 12 tackles for loss and 3 sacks.
Kiper ranks Delpit as the top draft-eligible safety and No. 10 overall prospect for the 2020 draft. He finished this past season with 65 tackles, including 2 sacks and 4.5 tackles for loss, to go with 2 interceptions, 7 pass breakups, a forced fumble and a fumble recovery.
Edwards-Helaire, Kiper's No. 8 running back, emerged as one of the best all-around backs in the country, rushing for 1,414 yards and 16 touchdowns to go along with 55 catches for 453 yards.
Whoever replaces Heisman Trophy-winning quarterback Joe Burrow will also be without Jefferson, Kiper's No. 7 receiver, and his team-leading 111 catches, 18 of which resulted in touchdowns.
It wasn't all bad news, though, as safety JaCoby Stevens and nose tackle Tyler Shelvin announced they would be returning next season. Stevens ranked second on the team in tackles (92) and third in interceptions (three).
ESPN's Adam Rittenberg contributed to this report.