Coach Ed Orgeron told reporters on Wednesday that Brennan, who is dealing with an abdominal/hip injury that has caused him to miss practice and games, will probably shut things down for the rest of the season. He added that the injury could require surgery.
"It doesn't look like he's going to be back, unless some miraculous thing happens," Orgeron said.
Brennan was one of the SEC's most productive passers before he was sidelined, throwing 11 touchdowns and three interceptions in three games.
Orgeron said he expects many of those quarantined players to return next week in time for LSU's scheduled game against Arkansas.