The Tigers and Trojans will play in the Vegas Kickoff Classic during Labor Day weekend in 2024 at Allegiant Stadium in a game to be aired on ABC or ESPN. The date of the game will be announced later.
USC and LSU have played only twice, splitting games in 1979 and 1984, and the Tigers will be making their first-ever appearance in Nevada.
"The opportunity to bring our team and the best fans in college football to Las Vegas is incredibly exciting," LSU athletic director Scott Woodward said in a statement. "We cannot wait to compete on the field and fill Allegiant Stadium with Tiger fans from across the country."
LSU had been set to open the 2024 season against UCLA, but the game has been rescheduled to Sept. 21 that season in Baton Rouge. The Tigers are set to open the 2021 season against the Bruins on Sept. 4 at the Rose Bowl; UCLA kicks off its season Saturday against Hawai'i.
Tigers coach Ed Orgeron had two stints as USC's defensive line coach and served as the Trojans' interim head coach in 2013, going 6-2.