Doeren said both players will need surgery, though he didn't specify the exact nature of the injuries.
Moore went down holding his knee during Saturday's loss at Miami. The redshirt junior later returned briefly before exiting a final time, sidelining a player who is the team's No. 2 tackler (43). It also marks the Wolfpack's fourth defensive starter lost to a season-ending injury this season, joining all-ACC linebacker Payton Wilson, safety Cyrus Fagan and nose tackle C.J. Clark.
The 6-foot-5, 325-pound Zavala, a graduate transfer from Fairmont State, started the first five games at left guard but didn't play in a win at Boston College nor the Miami loss due to injury.
The Miami loss knocked the Wolfpack out of the AP Top 25. NC State (5-2, 2-1 ACC) hosts Louisville on Saturday night.