Sale heads back to the SEC and reunites with new Florida coach Billy Napier, who he worked with at Arizona State and Louisiana. Sale was Napier's offensive coordinator/offensive line coach at Louisiana, where they set several school records on offense in 2019 and finished 19th in the College Football Playoff rankings in 2020.
Napier, who is planning on calling offensive plays in his first year in Gainesville, was hired to a seven-year deal to replace Dan Mullen with the Gators.
The Giants' season concluded with a sixth straight loss Sunday to Washington.
Sale's departure came hours before the Giants (4-13) made it official that coach Joe Judge would not return for a third season.
Sale, who worked with Judge previously at Alabama, just finished his first NFL season. He dealt with a line that was devastated by injury early in the season. The Giants ranked tied for 16th in the league in sacks allowed (38) and 24th in the league in rushing (99.3 yards a game).
Sale and Judge both declined to answer inquiries several weeks back about rumors surrounding a potential move to Florida.
The Giants hired Sale to replace Dave DeGuglielmo as their offensive line coach last offseason. They will now be looking for their fifth line coach in the past three years this offseason.
Sale, 42, was an offensive lineman at LSU from 1999 to 2002. He took his first college coaching job in 2007, as a strength and conditioning assistant and analyst with Judge at Alabama. He left Alabama in 2012 to coach the offensive line at McNeese State, and had the same role later at Georgia, Louisiana Monroe, Arizona State and Lafayette.
He was asked recently whether there was much of a difference coaching college and professional players.
"Nah, it's all ball in my opinion," Sale said. "It's important to the players to invest in them as people, as persons. They all have the same issues no matter if you're in college or the National Football League. We all have the same deals. You've still got the year-round plan that you have with these players getting them better over and over again and how you practice.
"One you pick your groceries and one you don't."
Sale will have some work to do in Florida. The Gators went 6-7 overall and 2-6 in the SEC this past season.
The Associated Press contributed to this report.