Collins, a 6-3 sophomore, leads the Tigers with five touchdown catches. He returned in in Saturday's loss to South Carolina after missing the two previous games because of a separated shoulder and had two catches, including a 59-yard grab that was Clemson's longest completion of the season.
Collins reinjured the shoulder against the Gamecocks and came back to the sideline with his arm in a sling.
Swinney said Collins would miss the ACC championship game against No. 24 North Carolina and the Tigers' bowl game.
He finished the season with 22 catches for 373 yards.