Wilson, who came in leading third-ranked Michigan in receptions (36), receiving yards (589) and receiving touchdowns (10), was shaken up after a 23-yard catch. He took a hard hit from Maryland's Dante Trader Jr., who was initially penalized for targeting but cleared following a review.
The 6-foot, 192-pound Wilson went to Michigan's injury tent and then to the locker room. He emerged in street clothes, wearing a "Free Harbaugh" T-shirt acknowledging suspended Michigan coach Jim Harbaugh.
Michigan acting head coach Sherrone Moore said he wasn't sure the exact nature of Wilson's possible head injury but noted that the medical staff ruling him out "was the responsible thing to do."
"He was fine from talking ... he was on the sideline afterward," Moore said.
Moore also said starting offensive tackle LaDarius Henderson would return for the Ohio State game after sitting out Saturday. He said Myles Hinton, who started in place of Henderson, left the game with a knee injury but had no structural damage.
Wilson's 10 touchdowns this season are the most by a receiver under Harbaugh. Wilson entered Saturday with 95 career receptions for 1,508 yards and 18 touchdowns, tied with Amani Toomer for eighth on Michigan's all-time list.
The senior from Hawai'i was named to the Biletnikoff Award watch list.