Nowitzki, who narrowly missed being voted in as a starter for the first time in his career, is the Mavericks' lone representative in the Valentine's Day event at Cowboys Stadium. It will be the ninth consecutive All-Star appearance for Nowitzki, who surpassed the 20,000-point milestone earlier this season and ranks seventh in the NBA in scoring (25.2 points per game).
"It is an honor to represent the Mavericks in my new hometown of Dallas," Nowitzki said. "I am always thankful for the opportunity to play in the All-Star game. We hope to put on a good show for our fans."
There will be no need for Nowitzki to play tour guide for some of the other reserves. Toronto power forward Chris Bosh, who attended Lincoln High in Dallas, will make his fifth consecutive All-Star appearance. Utah point guard Deron Williams will make his All-Star debut within a short drive of his hometown, The Colony, Texas.
Oklahoma City swingman Kevin Durant, who played at Texas, will also make his All-Star debut.
The reserves were chosen by the head coaches from each conference, who weren't allowed to vote for their own players. They had to select two guards, two forwards, one center and two players regardless of position.
Bosh, who averages 23.9 points and 11.3 rebounds, is the only player to rank among the league's top 10 in scoring and rebounding.
"Just to be able to be an All-Star year in and year out, that's a special feeling, but the fact that it's in Dallas is kind of a bittersweet thing," Bosh said before the Raptors faced the Knicks on Thursday. "Sweet because I get to play in front of my home crowd and it's bitter because everybody wants tickets."
The glut of great guards in the West has prevented Williams from making an All-Star appearance despite ranking among the NBA's assist leaders while scoring averaging 20 points game. Williams ranks fourth in in assists with 9.5 a game.
Durant averages more points (29.3) than every player in the league other than perennial All-Star starters Carmelo Anthony and LeBron James. His emergence has helped make the Thunder (24-21) legitimate playoff contenders in the loaded Western Conference.
Boston Celtics guard Rajon Rondo and Chicago Bulls guard Derrick Rose will make their All-Star Game debuts. Boston's Paul Pierce, Charlotte's Gerald Wallace, Bosh and Atlanta teammates Joe Johnson and Al Horford will also be on the Eastern Conference bench.
"There's going to come a day that they don't pick me," Pierce said in Orlando, where the Celtics are facing the Magic. "So every time I get a chance to make it, it's definitely an honor."
Horford likely edged out Lee, who is averaging 19.4 points and 11.4 rebounds for a Knicks team far below .500. Horford is averaging 13.6 points and 9.8 boards.
"It's out of my control and Coach [Mike D'Antoni] always tells me to try to control the things I can control and I think the overall message was that nobody was taken off a team with a sub-.500 record," Lee said. "So that means one thing: We've got to get some more victories, and that's what we'll go after right now."
Also left out was a second Cleveland player behind James. The Cavs felt point guard Williams should have been selected -- though he is injured, anyway.
"Mo has [played well] for us as our second-leading scorer and we're not going to be represented by anybody except for LeBron. It's tough but it's out of our control," Cavs coach Mike Brown said. "We have the best record in the league but there is nothing we can do about that. I don't know what it's going to take."
Rose and Wallace both have helped their teams surge to .500 records after terrible starts, and Wallace was rewarded with the first All-Star selection in Bobcats history.
"It's truly an honor to be named to the All-Star team," Wallace said. "This is an amazing moment for me and for the Bobcats franchise, and I'm excited to be the first player to represent this team in the All-Star game. I want to thank all the fans who voted for me and the coaches who selected me to play in the game."
Voted to start by the fans in the East were James, Boston's Kevin Garnett, Orlando's Dwight Howard, Miami's Dwyane Wade and Philadelphia's Allen Iverson. The West starters are the Lakers' Kobe Bryant, Steve Nash and Amare Stoudemire of Phoenix, Denver's Carmelo Anthony and San Antonio's Tim Duncan.
If any players are injured, commissioner David Stern would choose the replacement.
Tim MacMahon covers the Mavericks for ESPN Dallas. The Associated Press contributed to this report.