Serena Williams was seeded No. 17 for the US Open, nine spots higher than her current ranking of No. 26.
The U.S. Tennis Association announced the seedings for the main draws of women's and men's singles on Tuesday.
Williams was put one place behind her older sister, Venus.
The draw for the tournament is Thursday. Play begins Monday.
This will be the third Grand Slam tournament of Williams' return to competition since she gave birth to a daughter during the 2017 US Open last September, then dealt with health complications.
The 23-time major champion, who turns 37 next month, was the runner-up at Wimbledon in July.