Who should you start? Who should you sit? To help you set your fantasy football lineups and to avoid starting a player who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Week 1 is usually the healthiest of weeks, with no games that count having been played this season. As such, the inactives list is not nearly as robust as it will be in future editions of this article. Still, if everyone is healthy, there may be a few surprise team decisions as to who won't be dressing today. Stay tuned!
Refresh often for the latest information.
Sunday night game
Darnell Mooney, WR, CHI: Back -- Active
Eddie Goldman, DT, CHI: Knee -- OUT
Robert Quinn, LB, CHI: Back -- Active
Khalil Mack, LB, CHI: Groin -- Active
Tashaun Gipson Sr., S, CHI: Back -- Active
Eddie Jackson, S, CHI: Wrist -- Active
Duke Shelley, DB, CHI: OUT
4 p.m. ET games
Offense
Odell Beckham Jr., WR, CLE: Knee -- Inactive
Impact: Limited in practice all week, and it was always believed that he'd only play if he felt up to it. Apparently, he does not.
Chase McLaughlin, K, CLE: Hamstring -- Active
Impact: Chris Naggar had been called up as insurance, but is inactive. It's best to look elsewhere for your Week 1 fantasy kicker.
Preston Williams, WR, MIA: Foot -- Inactive
Impact: With William Fuller V serving out the last game of his suspension, rookie Jaylen Waddle has a chance to surprise.
Adam Shaheen, TE, MIA: COVID-19 -- OUT
Impact: Mike Gesicki and Cethan Carter to handle Miami's TE duties.
Malcolm Perry, WR, NE: Foot -- OUT/IR
Impact: N'Keal Harry is also on IR, so the WR pickings are slim beyond Kendrick Bourne and Jakobi Meyers.
Nelson Agholor, WR, NE: Ankle -- Active
Impact: Upgraded late in week. If he can't play a full 60 minutes, Gunner Olszewski becomes an option.
Saquon Barkley, RB, NYG: Knee -- Active
Impact: He has been medically cleared to play but is still likely to have some sort of limits to his snap count as a precaution.
Evan Engram, TE, NYG: Calf -- OUT
Impact: Kyle Rudolph and Kaden Smith get more looks.
Defense
Jadeveon Clowney, DE, CLE: Illness -- Active
Ronnie Harrison Jr., S, CLE: Ankle -- Active
Bradley Chubb, LB, DEN: Ankle -- Inactive
Za'Darius Smith, LB, GB: Back -- Active
Frank Clark, DE, KC: Hamstring -- Inactive
Derrick Nnadi, DT, KC: Hip -- Active
Tyrann Mathieu, S, KC: COVID-19 -- Inactive
Jalen Mills, CB, NE: Ankle -- Active
Marshon Lattimore, CB, NO: Knee -- Active
Adoree' Jackson, CB, NYG: Ankle -- Active
1 p.m. ET games
Offense
Wayne Gallman, RB, ATL: Inactive -- Team decision
Impact: Looks like Atlanta has confidence in Cordarrelle Patterson's ability to provide a change of pace for Mike Davis.
Emmanuel Sanders, WR, BUF: Foot -- Active
Impact: Gabriel Davis is the man to lean on if you believe Sanders might stumble during this week's game.
Zack Moss, RB, BUF: Team decision -- Inactive
Impact: Devin Singletary should have a huge day with this unexpected development.
Deshaun Watson, QB, HOU: Team decision -- OUT
Impact: Tyrod Taylor will lead the Texans, who would rather trade Watson than play him.
Ka'imi Fairbairn, K, HOU: Leg -- OUT/IR
Impact: Joey Slye will handle kicking duties, as Fairbairn is out for at least three weeks.
Austin Ekeler, RB, LAC: Hamstring -- Active
Impact: Practiced Friday and will be the RB1 for the Chargers on Sunday.
La'Mical Perine, RB, NYJ: Foot -- Inactive
Impact: Tevin Coleman is expected to be the lead option in a very crowded backfield.
Keelan Cole, WR, NYJ: Knee -- Inactive
Impact: Denzel Mims could step into a more important role for an already depleted Jets WR unit.
Jamison Crowder, WR, NYJ: COVID-19 -- OUT
Impact: Elijah Moore has a chance to make some Week 1 waves with the regular starter unable to suit up.
Jalen Hurd, WR, SF: Knee -- OUT/IR
Impact: Hurd will be out until at least Week 4. Mohamed Sanu Sr. and Trent Sherfield gain value.
Trey Sermon, RB, SF: Team decision -- Inactive
Impact: Raheem Mostert won't have to share the ball today.
Josh Reynolds, WR, TEN: Foot -- Inactive
Impact: Could Nick Westbrook-Ikhine make some waves? Cameron Batson is also inactive.
Sam Ficken, K, TEN: Groin -- OUT/IR
Impact: Michael Badgley has been promoted from the practice squad.
Defense
Star Lotulelei, DT, BUF: Calf -- OUT
Trae Waynes, CB, CIN: Hamstring -- OUT
Michael Brockers, DT, DET: Shoulder -- Active
Nick Williams, DT, DET: Elbow -- Active
Kevin Pierre-Louis, LB, HOU: Thigh -- Inactive
Xavier Rhodes, CB, IND: Calf -- OUT
Tre Herndon, CB, JAX: Knee -- OUT
Anthony Barr, LB, MIN: Knee -- OUT
Javon Kinlaw, DT, SF: Knee -- Inactive