Manning, the NFL's most valuable player in 2008, will tee off with Woods at 7:30 a.m. ET at Charlotte's PGA Tour stop, where Woods is making his first PGA Tour start since a tie for sixth at the Masters. Manning played with Kenny Perry last week in the Zurich Classic pro-am at New Orleans.
Woods is used to sharing the stage at this pro-am. In 2007, he asked to be paired with Michael Jordan for the event, and the pairing was easily the top draw of the day.
The tournament has attracted a top field, including Phil Mickelson, Sergio Garcia, Padraig Harrington and Masters champion Angel Cabrera. Manning has previously played in this Quail Hollow pro-am with Garcia. He also played a pro-am with Woods at the Arnold Palmer Invitational three years ago.
Three-time defending Nextel Cup champion Jimmie Johnson, driver Michael Waltrip, former NBA great Julius Erving and ESPN's Chris Berman are also scheduled to play in the Wednesday pro-am, which features a pro and two amateurs in every group.
Bob Harig covers golf for ESPN.com.