Crawford was fitted with a walking boot and said he would be going on the disabled list.
Dodgers manager Don Mattingly said it appears likely Crawford will indeed be put on the 15-day DL on Wednesday.
"It didn't look good, obviously," Mattingly said. "The video didn't look good; [trainer] Stan [Conte] didn't sound good. We always say we'll wait until tomorrow to see, but it didn't look very good."
Mattingly said X-rays of Crawford's ankle were negative. He was wheeled into the Dodgers' clubhouse after the game but limped into the showers without a crutch.
Crawford was racing into the corner to retrieve pinch hitter Chris Heisey's line drive when his ankle buckled.
He hobbled around before retreating to the dugout and being replaced by Scott Van Slyke.
Crawford was having a productive May after a slow start, batting .333 with four home runs this month.
If there's one area where the Dodgers can withstand an injury to a key player, it's the outfield. The team has been playing with four every-day-caliber outfielders most of the season.
The past two days, Matt Kemp has taken pregame balls in left field as the team tries to convert him from an every-day center fielder into a role player capable at more than one position.
The Dodgers had benched Kemp the past five games in order to insert Andre Ethier into center field to improve the club's often-shaky defense.
Kemp pinch hit in the eighth inning and struck out on four pitches against reliever J.J. Hoover.
Mattingly said he's not yet sure whether Kemp is ready to take over in left field. He hasn't played the position since 2006.
Mattingly said he would check with Kemp on Wednesday before deciding whether to play him.
"He's going to have to make that decision," Mattingly said. "I'm comfortable to put him out there, but I don't want him to get out there and feel like he's not ready for it."