Tyrus McGee had 15 points off the bench for the Cyclones (11-4, 1-1 Big 12), who bounced back from a heartbreaking loss at No. 6 Kansas by pounding the struggling Longhorns (8-8, 0-3).
Iowa State built an 11-point halftime lead and maintained a comfortable edge the rest of the way in beating Texas for just the second time in 11 tries.
Johnathan Holmes and Julien Lewis each had 15 points to lead the Longhorns.
Texas star Sheldon McClellan, the team's leading scorer at 15.2 points per game, played just one scoreless minute.
Louisville's Mike Pegues up to task as interim men's basketball coach: 'Not my first rodeo'
Louisville interim men's basketball coach Mike Pegues downplayed feeling any pressure as he tries to salvage the Cardinals' season after replacing Chris Mack.
Florida center Jason Jitoboh out remainder of the men's basketball season following eye surgery
Florida Gators center Jason Jitoboh will miss the remainder of the men's basketball season following eye surgery Friday.
Mathon scores 22 to lead Boston University by Colgate 76-72
— Sukhmail Mathon had 22 points and 11 rebounds as Boston University narrowly defeated Colgate 76-72 on Friday.