HARTFORD, Conn. -- Purdue's Carsen Edwards says he was getting tired of answering questions about his shooting slump.
Eric Paschall had 19 for Villanova (26-10), which saw its quest for a third national title in the past four seasons end during the tournament's first weekend. Fellow senior Phil Booth scored 15 points, putting him over 1,500 for his career.
Edwards has battled a sore back and coming into the tournament had hit just 32 percent from the floor in his previous 11 games.
Against Old Dominion in the first round he was not much better, scoring 26 points but on 7-for-23 shooting from the floor and 4-for-12 from behind the arc.
He found the bottom of the net early and often against Nova, making 12 of his 21 shots and nine 3-pointers on 16 attempts.
"I wouldn't say I knew I had a career night until the game was over," he said. "I was just so focused on trying to get the win, especially in games like this where you value every possession."
Purdue shot 53.7 percent while holding Villanova to just 20 baskets on 58 shots (34.5 percent).
It was the worst tourney loss in Villanova's storied NCAA tournament history and the largest blowout of a defending champion in nearly three decades, dating back to Loyola-Marymount's 149-115 dismantling of Michigan in 1990.
"This game is a humbling game," Villanova coach Jay Wright said. "We didn't get up on Edwards early, didn't get up on Cline early and when great shooters get hot, you're in trouble."
Purdue jumped out early, building a 13-point lead thanks to Edwards' outside shooting and Haarms' work down low.
The 7-foot-3 Dutchman towered over the shorter Wildcats, who didn't start anyone over 6-8.
Purdue had nine 3-point baskets in the first half and a dunk by Haarms put the Boilermakers up 43-24 at intermission.
Another dunk from the Dutchman extended the lead to 35 in the second half. Villanova chipped away but the sixth-seeded Big East champions did not have weapons to make it a game.
Villanova: The Wildcats continued a five-year pattern that has seen them lose in the second round, win a national title, lose in the second round and win another national title. The Wildcats are 15-3 in NCAA tournament games over that stretch.
Purdue: The win gives the Boilermakers 25 victories for the fourth straight season. Purdue had done that only once before, between 2008 and 2011.
Edwards' nine 3-pointers was a record for a game in Hartford's XL Center. The previous mark of eight was held by the most prolific 3-point shooter in NBA history, Ray Allen, when he played for UConn.
"That's crazy," Edwards said. "I'm blessed to be able to shoot the ball like that and to make 3s like that."
ONE MORE STEP
Purdue coach Matt Painter said as proud as he is of the consistency it takes to make it to the regional semifinals three years in a row, he's not looking at that as a great accomplishment.
"You know you're greedy as a coach," he said. "You look at it like you didn't advance further; you should have played better in conference play. We're excited about going to the Sweet 16, but we want to do better. We want to do better for ourselves and our fans."